Quantitative Assessment of Inner Ear Pathology Following Ototoxic Drugs or Acoustic Trauma

Protecting the Inner Ear from Acoustic Trauma.

Calcium activated proteases, or calpains, play an important role in neurodegeneration. In some cases, neural degeneration can be significantly reduced by leupeptin, a potent calpain inhibitor. To determine if leupeptin could protect against noise-induced hearing loss and hair cell loss, we infused leupeptin into scala tympani of one cochlea before, during and after a 14-day exposure to a 100 dB...

Growth Hormone Promotes Hair Cell Regeneration in the Zebrafish (Danio rerio) Inner Ear following Acoustic Trauma

BACKGROUND Previous microarray analysis showed that growth hormone (GH) was significantly upregulated following acoustic trauma in the zebrafish (Danio rerio) ear suggesting that GH may play an important role in the process of auditory hair cell regeneration. Our objective was to examine the effects of exogenous and endogenous GH on zebrafish inner ear epithelia following acoustic trauma. MET...

Social Rehabilitation and Independence of Individuals Following Trauma, Disease or Chronic Pathology

In recent years there has been an increase in the number of people requiring rehabilitation services. The genesis of rehabilitation services has been, in part, a response to the recognition that increasing the quality of life and independence of individuals following trauma, disease or enduring chronic pathology benefits society as a whole, as well as the individual. Human beings also have psyc...

Evidence for supporting cell mitosis in response to acoustic trauma in the avian inner ear.

Acoustic overstimulation can lead to sensory cell (hair cell) loss in the auditory epithelium. Damaged hair cells in the organ of Corti (the mammalian auditory end-organ) degenerate and are replaced by non-sensory cells (supporting cells) which construct an irreversible scar. In birds, however, auditory hair cells which are damaged by acoustic trauma or ototoxic drugs may be replaced by new hai...

Ototoxic effects from gentamicin ear drops.